How Alloantibodies Bind Foreign HLA
Learning Objectives
-Describe the parts of an antibody that form the antigen-binding site
-Define the meaning of the terms: epitope, paratope, eplet, cross-reactivity, affinity, and avidity
-Understand how the specificity of donor-specific antibodies is related to HLA polymorphism and structure
-Use tools to identify HLA polymorphisms that might be detected by alloantibodies