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How Alloantibodies Bind Foreign HLA

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Learning Objectives 

-Describe the parts of an antibody that form the antigen-binding site 

-Define the meaning of the terms: epitope, paratope, eplet, cross-reactivity, affinity, and avidity 

-Understand how the specificity of donor-specific antibodies is related to HLA polymorphism and structure 

-Use tools to identify HLA polymorphisms that might be detected by alloantibodies