Learning Objectives 

-Describe the antigen presentation pathways for class I and class II HLA molecules 

-Define the meaning of “T cell epitope” and describe why epitopes from the same pathogen might vary among individuals 

-Describe the complex interaction between HLA and pathogens that: 

          -Has shaped the HLA profile of the human population and 

          -Impacts the evolution of a pathogen. 

-Identify other receptors (Killer Immunoglobulin-like Receptor (KIR), Leukocyte Immunoglobulin-like Receptor (LILR)) that bind   HLA and may impact infection