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ASHI Journal Club 29 - HLA-B leader and survivorship after HLA-mismatched unrelated donor transplantation

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HLA-B leader and survivorship after HLA-mismatched unrelated donor
transplantation.

Petersdorf EW, Stevenson P, Bengtsson M, De Santis D, Dubois V, Gooley
T, Horowitz M, Hsu K, Madrigal JA, Malkki M, McKallor C, Morishima Y,
Oudshoorn M, Spellman SR, Villard J, Carrington M.
Blood (2020) 136:362-9

Learning objectives:
• Describe the immune barriers to unrelated donor hematopoietic cell
transplant (HCT)
• List the basic guidelines for unrelated HCT donor selection
• Identify the HLA-B leader peptide dimorphism and explain its clinical
relevance in HCT
• Utilize the free tools available for HLA-B leader assignment and
matching