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ASHI Journal Club #23 - Non-HLA Antibodies Associated with Cardiac Allograft Rejection

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Learning Objectives:

  • Some transplant recipients suffer rejection in the absence of donor specific antibodies (DSA) to HLA.  
  • Non-HLA antibodies (Abs) have been associated with an increased risk of acute rejection and chronic allograft injury in transplantation.
  • Currently, clinical tests for AT1R, MICA, and unknown endothelial cell membrane antibodies by endothelial cell cross match (ECXM) are available, and a research panel of non-HLA antibodies associated with cardiac allograft rejection has been developed and validated.